Minimizing genomic duplication episodes
نویسندگان
چکیده
منابع مشابه
Minimizing the number of episodes and Gallai's theorem on intervals
In 1996, Guigo et al. [Mol. Phylogenet. Evol., 6 (1996), 189–203] posed the following problem: for a given species tree and a number of gene trees, what is the minimum number of duplication episodes, where several genes could have undergone duplication together to generate the observed situation. (Gene order is neglected, but duplication of genes could have happened only on certain segments tha...
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The human genome is enriched in interspersed segmental duplications that sensitize approximately 10% of our genome to recurrent microdeletions and microduplications as a result of unequal crossing over. We review the recent discovery of recurrent rearrangements within these genomic hotspots and their association with both syndromic and nonsyndromic diseases. Studies of common complex genetic di...
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Whole-genome duplication approximately 10(8) years ago was proposed as an explanation for the many duplicated chromosomal regions in Saccharomyces cerevisiae. Here we have used computer simulations and analytic methods to estimate some parameters describing the evolution of the yeast genome after this duplication event. Computer simulation of a model in which 8% of the original genes were retai...
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ژورنال
عنوان ژورنال: Computational Biology and Chemistry
سال: 2020
ISSN: 1476-9271
DOI: 10.1016/j.compbiolchem.2020.107260